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Hemispheric Medulloblastoma
Case Detail
| Anatomy: Brain-Spine |
 Joseph Junewick, MD FACR |
| Diagnostic Category: Neoplasia Malignant |
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| Created: about 1 month ago |
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| Updated: about 1 month ago |
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| Tags:
PEDS
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| Modality/Study Types:
MR
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Activities:  PDF  ImageJA |
History
17 year old male with headache and vomiting.
Case Images
Diagnosis
Hemispheric Medulloblastoma
Findings
MR – Axial T1, T2-FLAIR, T2 and postgadolinium T1 images demonstrate a macrolobulated intermediate signal, minimally enhancing mass in the left cerebellar hemisphere.
Discussion
In children, medulloblastoma is typically a well defined tumor involving the vermis; on MR T1 signal is similar or lower than cortex, T2 signal is variable and enhancement is fairly uniform and intense. In adults, medulloblastoma is more peripherally located in the hemispheres and may or may not be well defined; signal and enhancement are more variable. The size and the presence of calcifications, edema and hydrocephalus are similar between adults and children. Medulloblastoma derives from pleuripotential cells of the germinal zone in the posterior medullary velum. During cerebellar development, these cell migrate peripherally to form the granular layer. Consequently, this peripheral migration appears to account for the age-related differences in tumor location.
Reference
Bourgouin PM, et al. CT and MR Imaging Findings in Adults with Cerebellar Medulloblastoma: Comparison with Findings in Children. AJR (1992); 159:609-612.