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Joseph Junewick, MD FACR
over 9 years ago
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Giant Cell Reparative Granuloma of the Mandible

Case Detail

Anatomy: Neck-Face
Joseph Junewick, MD FACR
Diagnostic Category: Neoplasia Benign
Created: over 9 years ago
Updated: over 9 years ago
Tags: PEDS
Modality/Study Types: CT
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Teenager with “cherubism”.

Case Images


Giant Cell Reparative Granuloma of the Mandible


CT – Axial and coronal images show marked expansion of the mandible by multi-septated lytic lesions. Bone survey shows polyostotic involvement.


Giant cell reparative granuloma is an uncommon lesion that is a reactive process and not a neoplasm. At histologic analysis, giant cell reparative granulomas demonstrate plump, bland fibroblasts and multinucleated giant cells surrounding foci of hemorrhage; osteoid production along hemorrhagic foci is commonly seen. The histologic appearance of GCRG is similar to that of brown tumor of hyperparathyroidism. GCRG occurs in patients in the 2nd and 3rd decades of life and has a predilection for the mandible and maxilla. Jaw lesions affect women more frequently than men (2:1 ratio). Patients present with pain and swelling; hormonal stimulation of pregnancy may lead to significant enlargement.


Murphey MD, Nomikos GC, Flemming DJ, et al. Imaging of Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone: Radiologic-Pathologic Correlation. RadioGraphics (2001); 21: 1283-1309.


Steven Waslawski, MD

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