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Highly primitive malignant neoplasm of the Pancreas
Case Detail
| Anatomy: Gastrointestinal |
 Joseph Junewick, MD FACR |
| Diagnostic Category: Neoplasia Malignant |
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| Created: over 3 years ago |
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| Updated: over 2 years ago |
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| Tags:
PEDS
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| Modality/Study Types:
US
CT
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Activities:  PDF  ImageJA |
History
4 year old male with elevated estrogen levels and gynecomastia.
Case Images
Diagnosis
Highly primitive malignant neoplasm of the pancreas with features of juvenile granulosa cell tumor.
Clinical Notes
Immunoperoxidase positivity for inhibin, CD10, calretin, estrogen receptors and progesterone receptors.
Findings
US – Hyperemic solid and cystic left upper quandrant mass.
CT – Well-circumscribed mass arising from the tail of the pancreas.
Discussion
Granulosa/theca cell tumors generally involve the gonads. These tumors are large at the time of diagnosis and usually solid but occasionally contain cystic components. Most granulosa/theca cell tumors produce estrogen, resulting in precocious development in females and gynecomastia in males.