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Orbital Pseudotumor
Joseph Junewick, MD FACR
over 5 years ago
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Hemosiderosis - Lymph Node

Case Detail

Anatomy: Vascular-Lymphatic
Junewick
Joseph Junewick, MD FACR
Diagnostic Category: Metabolic
Created: over 4 years ago
Updated: over 4 years ago
Tags: PEDS
Modality/Study Types: CT
Activities:
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History

Adult male with sickle cell disease.


Case Images


Diagnosis

Hemosiderosis – Lymph Node

Findings

CT- Axial and coronal noncontrast images demonstrate multiple enlarged and hyperdense lymph nodes in the periportal, retroperitoneal and mediastinal stations. Also note, the hepatic hemosiderosis and evolving splenic infarction.

Discussion

Hemolytic anemias result in the deposition of iron in the reticuloendothelial system and other organs (bowel, pancreas, adrenal glands, etc) related to increased turnover of red blood cells and multiple transfusions. Iron accumulates in macrophages secondary to red blood cell lysis; macrophages are eventually sequestered by the liver, spleen and lymph nodes. Attenuation coefficients of lymph nodes range between 145 and 205 HU and appear calcified (the atomic numbers of iron and calcium are similar measuring 26 and 20 AU respectively).

Reference

Mitnick JS, Bosniak MA, Megibow AJ, Karpatkin H, et al. CT in B-Thalassemia: Iron Deposition in the Liver, Spleen, and Lymph Nodes. AJR (1981); 136-1191-1194.

Contributor

David Pennes, MD



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